Istoricul terapiei antibacteriene

Abstract

In antiquity, many people have used different natural products, especially moulds, for treating infections. Although, many centuries during the human history were dominated by ignorance regarding the possibilities of fight against the infectious diseases, disasters are having decimated the world population. The first who has observed that some microorganisms can be used for the destructions of other was the scientist Louis Pasteur. A fundamental moment in the therapy of bacterial infections was the discovery of penicillin, in 1928, by Alexander Fleming, opening the era of antibiotics. Initially, there were used only extracts from microorganisms, afterwards this being extended by a wide range of synthetic and semi-synthetic substances with antibacterial properties. In 1943, after only 4 years of production and use of penicillin on a large scale, there were reported resistant strains to this antibiotic. The resistance of bacteria to antibiotics represents a public health issue of great concern in our days.