Possible utilization of some phase II enzymes biotransformation for xenobiotic determinations

Abstract

Exposure of human or animal to xenobiotics induces complex cellular responses (metabolic changes leading to adverse outcomes) results in perturbation of many events. The presence of xenobiotic substances (foreign molecules) in a living system can easily disrupt their balance by inhibiting, enhancing or interacting with one or more of the components or chemical reactions on which its situation depends. The present paper presented two phase II enzymes biotransformation UDP-glucuronosyltransferases and glutathione-S-transferases and their possible utilization in vitro, for detection of some xenobiotics.