Metode moderne de analiza a chinolonelor

Abstract

Quinolones are a modern class of antibacterial agents that have developed since the discovery of nalidixic acid to compounds with high potency, broad activity spectrum and improved absorption and distribution properties. The major qualitative leap occurred with the introduction of a fluorine atom in the 6th position of the quinoline cycle, resulting in fluoroquinolones, compounds with an increased chemotherapeutic potential. Taking in consideration their great therapeutic importance development of methods for their analysis was and still is a permanent necessity and challenge. Implementations of modern methods of analysis lead to a better understanding of quinolones in terms of chemistry, pharmacodynamics and conditioning. Development of new methods of analysis is closely linked with explosive evolution process of quinolones. The aim of this paper is to present a review regarding the methods used in the quinolones' analysis emphasizing on the modern methods of analysis and the latest developments in this scientific field.