Situsurile fragile şi patologia umană

Authors

  • Daniela Diaconescu Universitatea Transilvania din Brașov, România
  • Radu-Sorin Diaconescu Universitatea Transilvania din Brașov, România
  • Andreea Drilea-Marga Policlinica de Diagnostic Rapid, Braşov, România
  • Sebastian Toma Universitatea Transilvania din Brașov, România

Keywords:

fragile site, genes, tumour supressor genes, disease, cancer

Abstract

Fragile sites (FSs) are heritable gaps and breaks in chromosomes generated in vivo or by specific culture conditions. They are classified as rare or common depending on their frequency within the population. For the human genome, there are 31 rare FSs and 88 common FSs identified. Several rare or common FSs have been molecularly characterized, but few have been studied extensively. This study aimed to summarize the most important and extensively studied FSs and their relation to human pathology. Keywords:

Author Biographies

Daniela Diaconescu, Universitatea Transilvania din Brașov, România

Facultatea de Medicină

Radu-Sorin Diaconescu, Universitatea Transilvania din Brașov, România

Facultatea de Medicină

Sebastian Toma, Universitatea Transilvania din Brașov, România

Facultatea de Medicină

Downloads

Published

2011-01-01

Issue

No. 1 (2010)

Section

Referate generale