Direcţii de cercetare pentru posibile antipsihotice

Abstract

After more than half a century since the introduction of the first antipsychotic drug, and despite extensive research on the field, aspects such as efficacy (especially on negative and cognitive symptoms) in schizophrenia, social integration of schizophrenic patients, or relapse rate after currently available treatments are far from having idealistic values. The present paper aims to summarize the available data on the main lines of research for developing future therapies in schizophrenia, from modulation of neurotransmitter systems involved in pathogeny or physiopathology of psychosis (dopaminergic, glutamatergic, serotoninergic, cholinergic, adrenergic, and others systems, more recently involved), to neurotrophic factors.