Evaluarea eficientei administrării precoce a surfactantului în sindromul de detresa respiratorie idiopatica a nou născutului | [The Evaluation of Early Surfactant Replacement Therapy Efficiency in Neonatal Respiratory Distress Syndrome]

Abstract

Studies indicated that surfactant replacement therapy is more effective if the lung injuries are not present. Objective: To evaluate if early surfactant replacement therapy decreases the duration of both oxygen administration and mechanical ventilation and also improves the survival rate. Method: This is a retrospective study analyzing the respiratory therapy in our unit between 1999 and 2005. The 1st group (study group) consists of 15 patients who received surfactant during the first 2 hours of life (early administration). The 2nd group consists of 22 patients who received surfactant after the first 2 hours of life. Results: The average gestational age and birth weight were 29 weeks and 1252 grams (1st group) respectively 29.09 weeks and 1280 grams (2nd group). The mean duration of oxygen administration was 8.7±2.41 days for the 1st group and 9.77±3.11 days for the 2nd group (t= -0.25, p > 0.05). The mean duration of mechanical ventilation was 2.89±2.22 days for the 1st group and 1.97±1.79 days for the 2nd group (t = 1.16, p > 0.05). The survival rate was better in the 1st group but without a statistical difference (p = 0.549). Conclusion: The early surfactant replacement therapy had improved the survival rate but without statistical difference. We need a more extensive study for more relevant statistical results. Although animals can ingest large amounts of nitrates in feed and water, however, nitrate and nitrite content of meat and eggs is very low. This is explained by the fact that nitrates are absorbed inside the small intestine easily pass into the bloodstream and are excreted through the kidneys. In herbivorous ruminant animals, most of the existing nitrates in feed are used as feedstock for nitrogenous organic substances by organisms that inhabit their stomachs. A small amount of nitrates can secrete the milk. In general, concentration does not exceed 40-50 mg/litter.