Semnificaţia expresiei proteinei P53 în carcinoamele prostatice şi metastazele lor limfoganglionare | [Significance of P53 protein expression in prostate carcinomas and their metastases]

Abstract

P53 tumour suppressor gene is the most frequently altered gene in human cancers. In this study, an analysis of p53 expression for 40 primary prostatic tumours and their lymph node metastases was performed. P53 expression was studied using immunohistochemistry with monoclonal antibody anti-p53. Tumour expression of p53 protein was considered when strong nuclear staining was present and was evaluated as a per cent of immunoreactive p53 cells. 23 of 40 primary tumours (57.5%) and 14 of 20 metastases (70%) revealed strong nuclear positivity for p53. Lymph node metastases showed significantly higher p53 expression than primary tumours. Our results indicate that altered expression of p53 is associated with increased proliferative activity and support the hypothesis that mutation of p53 is an early event in prostate carcinoma progression.