Condiții necesare pentru dezvoltarea osificărilor heterotopice | [Necessary conditions for heterotopic bone formation]

Authors

  • Iosif Șamotă Universitatea Transilvania din Brașov, România
  • Radu Dan Necula Universitatea Transilvania din Brașov, România
  • Florin Lucian Petrică Sabou Spitalul Clinic Județean de Urgență Brașov, România

Keywords:

heterotopic ossifications, BMP, mesenchymal stem cells

Abstract

Heterotopic ossification is defined as the presence of mature lamellar bone in soft tissues such as muscles, tendons, skin, or organs, where bone normally doesn't exist. It can appear more frequently as a complication following central nervous system disorders like acute brain injuries, brain tumors, or spinal cord injuries, or following burns, hip and elbow surgery. For heterotopic bone formation, some local and general specific conditions are necessary. The three main conditions are the presence of a morphogenetic induction agent, mesenchymal progenitor stem cells, and a permissive local and general environment.

Author Biographies

Iosif Șamotă, Universitatea Transilvania din Brașov, România

Facultatea de Medicină

Radu Dan Necula, Universitatea Transilvania din Brașov, România

Facultatea de Medicină;
Spitalul Clinic Județean de Urgență Brașov
Secția Clinică Ortopedie

Florin Lucian Petrică Sabou, Spitalul Clinic Județean de Urgență Brașov, România

Secția Clinică Ortopedie

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Published

2015-07-28

Issue

No. 1 (2015)

Section

Referate generale