Modificările genetice și influența acestora în determinismul retardului de creștere intrauterină | [Genetic changes and their influence in the intrauterine growth restriction determinism]

Abstract

Intrauterine growth restriction of the fetus (RCIU) is so far one of the most complex issues of obstetrics, representing a common complication of pregnancy where the fetus can be defined as the failure to reach the genetically programmed size. Genetic polymorphisms, maternal, placental, and fetal are responsible for encoding proteins and hormones, being shown to influence fetal growth. Among the best-known genetic causes of intrauterine growth retardation are found in placental, maternal, and fetal genes. This paper presents a review of genetic changes found in intrauterine growth retardation, especially those related to placental genes, with predilection IGF, placental growth factor, and other genetic mutations.