Gonoreea – o boală netratabilă în viitor? | [Gonorrhea - an untreatable disease in the future?]

Abstract

Despite the advances that have occurred in the diagnosis and treatment of sexually transmitted diseases (STDs), they remain a public health problem worldwide. Of all etiologic agents of treatable STDs, Neisseria gonorrhoeae has the highest versatility to acquire antimicrobial resistance and high antigenically variability by circumventing the host defense. Currently, it is estimated a high prevalence of N. gonorrhoeae strains with resistance to most antimicrobial agents previously and currently available (sulfonamides, penicillins, cephalosporins, tetracyclines, macrolides, and fluoroquinolones) which causes great concern. This review analyzes the history and evolution of gonorrhea treatment regimens and acquired resistance to these therapies over time, and gonococcal antimicrobial resistance phenotypes to previously and currently recommended therapy.