Metastazarea: Aspecte moleculare | [Metastasis: Molecular aspects]

Abstract

Metastasis is a complex process, requiring the cancer cells first to release themselves from their intercellular adhesive bonds, then leave their cellular microenvironment and migrate through the connective tissue matrix in order to gain access to the blood vessels that carry them to a new organ. Once there, the malignant cells have to pass through the vasculature in the new organ, forming there new connections. This article is a review of the most recent hypothesis concerning the molecular mechanisms of metastasis and angiogenesis and their potential impact on cancer therapy.