Bulletin of the Transilvania University of Brasov. Series VI: Medical Sciences

https://webbut.unitbv.ro/index.php/Series_VI/issue/feed Bulletin of the Transilvania University of Brasov. Series VI: Medical Sciences 2026-01-27T08:08:46+00:00 Prof. Dr. MD Alina PASCU editor.but@unitbv.ro Open Journal Systems <h2>Aim</h2> This is a medical multidisciplinary journal publishing original research papers, and case presentations. The yearly journal presents the latest results in medical research, focusing on integrated, interdisciplinary approaches. Also, it is committed to publishing work on different fields of the health profession and the history of medicine. The aim of the journal is to promote excellence and is open to research groups all over the world and mostly welcomes scientific papers from groups involving young researchers. The Journal is indexed in EBSCO Publishing DataBase (<a href="http://webbut.unitbv.ro/public/site/documents/admin/a9h-subject.xls">http://www.ebscohost.com/titleLists/a9h-subject.xls</a>), from 2010, ProQuest Central (<a href="https://search.proquest.com/central/" target="_blank" rel="noopener">https://search.proquest.com/central/</a>), from 2008, and in Crossref (<a href="https://search.crossref.org" target="_blank" rel="noopener">https://search.crossref.org</a>), from January 2019. Senior-editor, Marius IRIMIE <a href="http://webbut.unitbv.ro/index.php/Series_VI/about" target="_blank" rel="noopener">Read more</a> https://webbut.unitbv.ro/index.php/Series_VI/article/view/11288 Addressing Health Misinformation, Public Health Surveillance, and Infection Control Using Public School Nurses 2026-01-27T07:14:12+00:00 Darrell Norman Burell darrell.burrell@yahoo.com

Infection prevention and control (IPC) is a critical component of public health, yet its application within U.S. K–12 schools remains fragmented, under-resourced, and insufficiently examined. Despite serving nearly 50 million students daily, public schools lack the standardized IPC infrastructure common in clinical environments, creating a significant and underrecognized public health vulnerability. This study addresses a critical gap in the literature by offering one of the first comprehensive examinations of school nurses’ strategic role in leading IPC efforts within educational settings. School nurses occupy a unique position at the intersection of healthcare delivery, education, and community engagement, yet their potential to influence disease prevention, health literacy, and illness surveillance remains largely untapped. Drawing on expert interviews and field-based insights, this research identifies context-specific, equity-centered strategies that enable school nurses to operationalize IPC more effectively, particularly in underserved communities. The study highlights how institutional constraints, misinformation, and inconsistent policies limit IPC effectiveness and contribute to disparities in student health outcomes. By centering school nurses as frontline public health practitioners, this research advances a novel, practice-informed framework for school-based IPC implementation. It fills a critical void in public health scholarship by reframing schools as active sites of disease prevention and positioning school nursing offices as essential nodes in community health resilience and surveillance systems.

2026-01-26T00:00:00+00:00 Copyright (c) 2025 Bulletin of the Transilvania University of Brasov. Series VI: Medical Sciences https://webbut.unitbv.ro/index.php/Series_VI/article/view/11289 Genetic and Molecular Determinants of Pemphigus Vulgaris and their Therapeutic Implications 2026-01-27T07:26:00+00:00 Marius Irimie marius.irimie@unitbv.ro

Pemphigus vulgaris (PV) is a rare, potentially life-threatening autoimmune blistering disease driven by pathogenic IgG autoantibodies targeting desmosomal cadherins (primarily desmoglein-3 and desmoglein-1), leading to loss of keratinocyte adhesion (acantholysis). Beyond antibody-mediated mechanisms, convergent evidence supports a strong genetic contribution to disease susceptibility, phenotype, and therapeutic response. This expanded narrative review synthesizes classical and emerging genetic determinants of PV, including HLA class II associations, non-HLA immune modifiers, desmosomal/epithelial susceptibility genes, genome-wide association study (GWAS) loci, epigenetic and transcriptomic signals, and integrates contemporary therapeutic advances (rituximab, FcRn inhibitors, BTK inhibition, and antigen-specific cell therapies). We highlight genotype-phenotype relationships, ethnic differences in risk alleles, translational biomarkers, and future directions for precision medicine in PV.

2026-01-26T00:00:00+00:00 Copyright (c) 2025 Bulletin of the Transilvania University of Brasov. Series VI: Medical Sciences https://webbut.unitbv.ro/index.php/Series_VI/article/view/11290 Yellow Fever Vaccination – Lifelong Protection Through a Single Dose: a Narrative Review 2026-01-27T07:53:58+00:00 E.M. Constantinescu elena.constantinescu@unitbv.ro C. Taposu taposu1@yahoo.com A.C. Constantinescu cristian.constantinescu@unitbv.ro

Yellow fever, caused by a flavivirus transmitted by Aedes and Haemagogus mosquitoes, remains a major public health concern in the tropical regions of Africa and South America, affecting approximately 900 million people living in at-risk areas. The live attenuated 17D vaccine, developed by Max Theiler in the 1930s and awarded the Nobel Prize in 1951, is one of the most effective vaccines ever created, providing lifelong immunity with a single dose to over 95% of vaccinees. This comprehensive narrative review examines the immunological mechanisms behind the substantial and durable effects of the vaccine, its historical development from the Asibi strain to the current 17D substrain, current vaccination strategies, contraindications, and the risk–benefit analysis. While the vaccine has an excellent safety profile with rare serious adverse events (0.09–0.4 per 10,000 doses), the benefits far outweigh the risks for most populations, contributing to the elimination of yellow fever as a major public health threat.

2026-01-26T00:00:00+00:00 Copyright (c) 2025 Bulletin of the Transilvania University of Brasov. Series VI: Medical Sciences https://webbut.unitbv.ro/index.php/Series_VI/article/view/11291 Severe Complications in Pediatric Cystic Fibrosis: Overcoming the Challenges (case reports) 2026-01-27T08:08:46+00:00 L.L. Dracea laura.dracea@unitbv.ro A. Bancila bancila1@yahoo.com

Cystic fibrosis (CF), is an autosomal recessive disorder caused by mutations in the CFTR gene, leading to atypical ion transport across epithelial cells and resulting in thick mucus accumulation. This condition significantly affects multiple organ systems, particularly the respiratory and gastrointestinal tracts, leading to infections and progressive dysfunction. The introduction of CFTR modulator therapies has dramatically improved life expectancy, now reaching approximately 50 years in high-income countries. This paper presents two CF cases from the Emergency Clinical Children’s Hospital of Brașov, facing severe, life-threatening complications. One patient successfully overcame a complication related to CF, while the other experienced a significant COVID-19 complication, while presenting as a pulmonary exacerbation (PEx) of CF. The cases highlight the challenging clinical outcomes in CF and personalized approach. Intravenous antibiotic use, as piperacillin/tazobactam, one of the mainstay interventions for PEx due to its effectiveness against Pseudomonas aeruginosa, may rarely lead to severe adverse events, such as drug-induced thrombocytopenia. Furthermore, although respiratory viral infections may adversely affect pulmonary status in CF patients, emerging evidence suggests that SARS-CoV-2 infection did not severely impact this group. Paediatric inflammatory multisystem syndrome (PIMS) associated with SARS-CoV-2 infection has to be considered even in CF patients with scarce symptoms, underscoring the challenge of potential complications.