In Patients with Non-St Acute Coronary Syndrome Diabetes Mellitus and Metabolic Syndrome have an Important Impact on Prognosis, Left Ventricular Systolic Function, Inflammatory Syndrome and Oxidative stress

Abstract

Aims: To evaluate oxidative stress, inflammatory syndrome, left ventricular systolic function and prognosis in patients with non ST acute coronary syndrome and metabolic syndrome or diabetes mellitus. Methods: 172 patients (pts) with non ST acute coronary syndrome (ACS) were included in a prospective study for a period of 3 years and were divided in three groups in relation with association of metabolic syndrome (MS) or diabetes mellitus (DM). Results: In non ST ACS patients, presence of metabolic syndrome or diabetes mellitus were associated with significant higher incidence of inflammatory syndrome (p< 0.05) and oxidative stress (p< 0.05) at 1 and 6 months and with a significant increased incidence of left ventricle systolic dysfunction (p< 0.05) at 1,2 and 3 years. Incidence of cardiovascular death, acute myocardial infarction, and unstable angina with readmission, at 1.2 and 3 years were significantly higher (p< 0.05) in comparison with ACS nonMS nonDM group. It was no significant differences between non ST acute coronary syndrome with metabolic syndrome and with diabetes mellitus groups at 1.2 and 3 years of follow up. Conclusions: In non ST acute coronary syndrome patients, presence of metabolic syndrome or diabetes mellitus were associated with a significant higher incidence of inflammatory syndrome, oxidative stress at 1 and 6 months, and a significant higher incidence of low ejection fraction, unstable angina with readmission, acute myocardial infarction and cardiovascular death at 1.2 and 3 years of follow up.