Prognostic Significance of Volume-Weighted Mean Nuclear Volumes in Prostate Adenocarcinomas

Abstract

This study investigated the correlation of stereologically estimated volume-weighted mean nuclear volumes (MNV) with the Gleason score in prostate adenocarcinomas. To assess the MNV the point sample intercepts method was used. MNV was significantly associated with tumor differentiation, suggesting that estimates of MNV are prognostically equal or superior to morphological grading of malignancy, such as Gleason score, in prostate cancer.