Antimicrobial Resistance of Klebsiella Strains Isolated from Hospitalized Patients

Abstract

Klebsiella, a bacterial genre that includes species frequently involved in human pathology, produces a wide range of infections, sometimes severe and difficult to treat. Our retrospective study was made in the Clinical County Emergency Hospital of Brasov and included the Klebsiella strains isolated from various pathological products of the patients hospitalized in 2010. The study shows the wide involvement in the pathology of Klebsiella genre, more frequent in urinary infections (63.6%), wound infections (10.4%), and lower respiratory tract infections (10%). Generally, the non-ESBL Klebsiella species have preserved sensitivity to antimicrobials of different classes. The share of Klebsiella ESBL-producing strains was very high in the studied period which represents a reason for serious concern and sustains the importance of optimizing the prescription of antibiotics. Carbapenems remain the first choice for the treatment of severe infections with ESBL-producing strains. Colistin, amikacin, and ciprofloxacin can be considered therapeutic solutions in some clinical situations.