Assessment of Oxidative Stress in Patients with Acute Ischemic Stroke

Abstract

A lot of studies showed the role of oxidative stress in more than 100 diseases, many neurodegenerative diseases and also in ischemic stroke. Objective: to assess the variation of oxidative stress in the acute phase of ischemic stroke and to find if there is any correlation with the clinical status or with any other biochemical parameter. Methods: We prospectively studied markers of oxidative stress – Total Antioxidant Status (TAS), uric acid, albumin, and copper - in 27 patients with acute ischemic stroke compared with 19 controls. Results and conclusions: We found mean levels for TAS and copper lower in patients with acute ischemic stroke than in controls. Levels of TAS correlated almost linearly with uric acid but not with albumin or copper. TAS correlated with NIHSS score in patients who presented higher or lower levels of one of the individual oxidative stress markers – uric acid, albumin, or copper.