Factors Associated with Severe Fibrosis in Chronic Hepatitis C

Abstract

The paper presents an epidemiological, biological, virological, and histological study of patients suffering from chronic viral hepatitis C with severe fibrosis whose aim was to identify the main etiological factors of the disease. The main characteristics for the group were advanced age, alcohol consumption, severe cytolytic syndrome, high viral load values, severe necroinflammatory lesions, alcohol-induced histological lesions, and biliary pathways pathology – leading to a pathological entity that is very severe, with a strong potential towards cirrhosis and hepatocellular carcinoma.