Inhibition of Reserpine-Induced Ulcers by Calcitonin in Rats

Authors

  • L. Nedelcu Transilvania University of Brasov, Romania
  • D. Grapa Iuliu Hatieganu University of Medicine and Pharmacy Cluj-Napoca, Romania
  • V. Sandor Iuliu Hatieganu University of Medicine and Pharmacy Cluj-Napoca, Romania
  • P. Orbai Iuliu Hatieganu University of Medicine and Pharmacy Cluj-Napoca, Romania
  • D.L. Dumitrascu Iuliu Hatieganu University of Medicine and Pharmacy Cluj-Napoca, Romania

Keywords:

calcitonin, reserpine, gastric mucosa, experimental ulcers, rats

Abstract

Reserpine has a net ulcerative effect, generating lesions of the glandular mucosa in rats at 8 hours after administration of a dose of 5 mg/kg IP. Gastric ulcerations can be present in a reduced proportion in the control group after a long fasting period. Calcitonin in repeated doses of 10 UI / kg and 100 UI / kg completely protects the animals against the ulcerative effects of reserpine and fasting. Interferences between calcitonin and reserpine, have as effect on the gastric protection exerted both peripheral and on the central nervous system.

Author Biography

L. Nedelcu, Transilvania University of Brasov, Romania

Faculty of Medicine

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Published

2011-09-28

Issue

Vol. 4(53) No. 1 (2011)

Section

MEDICAL SCIENCES