The Dynamics of Resistance to Quinolones in Gram Negative Bacteria Isolated from Hospitalized Patients

Abstract

Quinolones are one of the largest classes of antimicrobial agents, including synthetic drugs frequently used worldwide. The study group included all the Gram-negative bacilli isolated from the pathological products of the patients hospitalized in the Clinical County Emergency Hospital of Brasov during a period of two years (2008 and 2010). The aim of the study has consisted of the evaluation of the dynamics of the resistance to quinolones of the isolated germs. The results showed that resistance to quinolones was present in all tested bacterial genres. In dynamics, we have found an increase in the level of resistance of non fermentative gram-negative bacilli to ciprofloxacin. There were also recorded increases in the percentage of resistance of Enterobacter strains to norfloxacin and to nalidixic acid in the case of Proteus strains. The relatively high level of resistant strains to quinolones shows the necessity of a rational policy in prescribing these antibiotics in hospitals.