Systemic Therapy of Moderate and Severe Psoriasis with Methotrexate

Abstract

The systemic treatment in psoriatic disease is addressed particularly to the severe forms of psoriasis with a PASI> 10. It consists of both conventional therapies (methotrexate, PUVA, cyclosporine, retinoids) and modern therapies with biological preparations. In this study, we made a comparative assessment of the effectiveness and tolerance of systemic treatment with methotrexate both as monotherapy and in combination with SUP phototherapy, for patients with psoriasis vulgaris. Key words: psoriasis, methotrexate, phototherapy.