Fanconi Anemia – Rare Cause of Pancytopenia at Child

Abstract

In this article, we present two cases of children (sister and brother) who present Fanconi anemia. Fanconi aplastic anemia was discovered in 1927. In 99% of the cases, it is transmitted autosomal recessive. The ratio between the sexes is about equal. It is usually diagnosed in children between 5-15 years. A positive diagnosis is based on the following criteria: 1. clinical (morphological abnormalities, anemic syndrome, infection, bleeding), 2. hematologic (pancytopenia, macrocytic anemia, and marrow failure), 3. chromosome fragility.