The Relationship between Proinsulin, Insulin Resistance and Serum Lipoproteins among Adults

Authors

  • S. Ateia University of Medicine and Pharmacy ”Carol Davila”, Bucharest, Romania; Medas Clinic, Bucharest, Romania
  • E. Rusu University of Medicine and Pharmacy ”Carol Davila”, Bucharest, Romania
  • Si. Ateia Medas Clinic, Bucharest, Romania
  • V. Cristescu University ”Titu Maiorescu”, Bucharest, Romania
  • A. Costache University of Medicine and Pharmacy ”Carol Davila”, Bucharest, Romania
  • G. Enache County Emergency Hospital Calarasi, Romania
  • G. Radulian University of Medicine and Pharmacy ”Carol Davila”, Bucharest, Romania
  • D. Cheta National Institute of Diabetes, Nutrition and Metabolic Diseases ”Prof. Nicolae Paulescu”, Bucharest, Romania

Keywords:

insulin resistance, obesity, proinsulin, TyG index

Abstract

The purpose of this study is to evaluate the relationship between proinsulin (FPP), insulin resistance and serum lipoproteins among adults and efficacity of these paraclinical indicators to identify the insulin resistance (IR). In this study we included 224 subjects without diabetes. Insulin resistance was present in 25% (n=56) of the participants. In all patients, ROC analysis demonstrated that product of tryglicerides and glucose (TyG index) was the strongest predictor of IR (HOMA-IR>3.04), folowed by FPP and tryglicerides (overall p< 0.0001). The TyG index, FPP and the TG/HDL-C ratio showed the greatest ability to predict IR. In normoponderal subjects, the ROC curve analyses showed that FPP was the best marker of insulin resistance.

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Published

2014-01-07

Issue

Vol. 6(55) No. 2 (2013)

Section

MEDICAL SCIENCES