Validation of a Murinic Model of Sepsis Induced by Cecal Ligation and Puncture Technique

Authors

  • M. Marginean Emergency Military Hospital, Cluj-Napoca, Romania
  • A. Ardelean-Maghiar (Marginean) Emergency Military Hospital, Cluj-Napoca, Romania
  • F. Sular Emergency County Hospital, Targu-Mures, Romania
  • D. Dobreanu University of Medicine and Pharmacy, Targu-Mures, Romania

Keywords:

sepsis, cecal ligation and puncture, CLP, rat, animal model

Abstract

Sepsis is considered to be a systemic response to an infection. This pathology is an common cause for mortality and morbidity being the primary cause of death among patients in the Intensive Care Units. Because of the increasing need for a standardised animal model of sepsis we decided to validate a murinic one using the cecal ligation and puncture (CLP) technique and easy to obtain physiologic and laboratory parameters.

Author Biographies

M. Marginean, Emergency Military Hospital, Cluj-Napoca, Romania

Anaesthesia and Intensive Care | www.smucluj.ro

A. Ardelean-Maghiar (Marginean), Emergency Military Hospital, Cluj-Napoca, Romania

Laboratory | www.smucluj.ro

F. Sular, Emergency County Hospital, Targu-Mures, Romania

Central Laboratory | www.spitjudms.ro

D. Dobreanu, University of Medicine and Pharmacy, Targu-Mures, Romania

Physiology Department | www.umftgm.ro

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Published

2014-01-07

Issue

Vol. 6(55) No. 2 (2013)

Section

MEDICAL SCIENCES