Label-Free Methods for Real-Time Analysis used in Oxidative Stress Biomarkers Detection

Abstract

For human body, oxidative stress is considered pathophysiological mechanism in different pathologies therefore oxidative damage biomarkers detection is real help for clinical purposes. Easy to use devices that can help in the early diagnosis and innovative therapeutic approaches are needed. This paper presents an extensive review of sensitive and specific devices such as biosensors used for real-time detection of oxidative stress biomarkers based on two label-free methods: Electrochemical Impedance Spectroscopy and Surface Plasmon Resonance. Both type of biosensors show very good performances and they are shown to be a viable alternative to conventional methods for oxidative stress biomarkers detection.