Hormonal Fluctuations Related to Depressive Symptoms in Menopause

Abstract

Depression has a high incidence among perimenopausal women. This systematic review focuses on the connection between hormonal fluctuations and depressive symptoms. The 5% chances of depression are correlated with increasing additional years between menarche and the menopausal transition (MT) onset. The higher rates of depressive symptoms were associated with more substantial variation in serum estradiol. Progesterone values higher than 6 ng / dL have been linked with lower rates of depressive symptoms. These results may also indicate an interaction between ovarian hormones, serotonin deficiency, and cortisol levels after menopause.