Genetic Aspects in the Colorectal Polyps Carcinogenesis

Authors

  • M. Stoian University of Medicine and Pharmacy ”Carol Davila”, Bucharest; Internal Medicine Department, ”Dr. Ion Cantacuzino” Clinical Hospital, Bucharest, Romania
  • N. State University of Medicine and Pharmacy ”Carol Davila”, Bucharest; Internal Medicine Department, ”Dr. Ion Cantacuzino” Clinical Hospital, Bucharest, Romania
  • E. Rusu University of Medicine and Pharmacy ”Carol Davila”, Bucharest; National Institute of Diabetes, Nutrition and Metabolic Diseases, Bucharest, Romania
  • V. Stoica University of Medicine and Pharmacy ”Carol Davila”, Bucharest; Internal Medicine Department, ”Dr. Ion Cantacuzino” Clinical Hospital, Bucharest, Romania
  • G. Radulian University of Medicine and Pharmacy ”Carol Davila”, Bucharest; National Institute of Diabetes, Nutrition and Metabolic Diseases, Bucharest, Romania
  • I. Pantea Transilvania University of Brasov, Romania
  • L. Nedelcu Transilvania University of Brasov, Romania

Keywords:

carcinogenesis, colorectal cancer, alkaline carcinogenetic agents

Abstract

Colorectal cancer, one of the most frequent cancers worldwide, is more prevalent in North America, Argentina, Australia, New Zealand, Western Europe, Japan, and Israel and, for this reason, is commonly regarded as a Western lifestyle disease. The progressive introduction of Western dietary habits, especially increased fat intake and reduced carbohydrate and dietary fiber intake is associated with an increased incidence of colorectal cancer and related deaths. This is the reason for a marked interest in the understanding of cell and molecular mechanisms underlying the carcinogenetic processes. The advanced neoplasm, including colorectal cancer, contains a large number of genetic and molecular alterations that contribute to their neoplastic progression. It is well known that early detection of malignancies in different tissues is quite important for reducing the disease. Cancer that is of epithelial origin is caused by both external and internal factors. These causal factors may act together or in sequence to initiate and /or promote cancer. In spite of knowing more than ever about the genetic and cellular events that can accelerate or inhibit cancer induction, cancer is still the number one health concern in the world, especially in Western and Westernized countries.

Author Biographies

I. Pantea, Transilvania University of Brasov, Romania

Faculty of Medicine

L. Nedelcu, Transilvania University of Brasov, Romania

Faculty of Medicine

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Published

2014-07-16

Issue

Section

MEDICAL SCIENCES