Simulation of an Adaptive Closed Loop System for Blood Glucose Concentration Control

Abstract

The main objective of this paper is to set up an adaptive control strategy for a closed loop system to control the glucose concentration in blood by delivering variable dosage of insulin. Simulations are done using the modified Bergman’s minimal model for type 1 diabetes mellitus patients. Based on this nonlinear model, an adaptive controller is proposed and tested in simulations. Good results confirm the efficiency of adaptive techniques for controlling the glycaemia level in diabetic patients, even when unexpected disturbance occurs, as having meals with different quantity of carbohydrates.